Fat Domino was one of the most influential figures in early rock and roll, known for his catchy melodies, boogie-woogie piano style, and rich, New Orleans-flavored rhythm. His discography spans several decades, with a blend of rhythm and blues, rock, and pop that helped shape the sound of American popular music in the 1950s and beyond.

Fat Domino's music career began in the late 1940s, but his first major breakthrough came in 1950 with the release of "The Fat Man," which became one of the first million-selling R&B records. This track showcased his signature sound—an infectious combination of blues, boogie-woogie, and a rhythmic piano-driven style. His early work, including hits like "Goin' Home" (1952) and "Ain't That a Shame" (1955), solidified his place in the birth of rock and roll.

Domino's success continued into the mid-1950s with a string of hits that crossed over from the R&B charts to the pop charts. Songs like "Ain't That a Shame," "Blueberry Hill" (1956), and "I'm Walkin'" (1957) became definitive rock and roll anthems. "Blueberry Hill" is particularly notable for its timeless appeal and remains one of Fat Domino’s most enduring tracks.

This era also saw the release of several important albums, such as Fat Domino Swings (1957), where he showcased his jazz influences, and Here Stands Fat Domino (1959), which featured a mix of rock, R&B, and jazz-inspired songs.

While the 1960s saw the rise of new musical styles like the British Invasion and folk rock, Fat Domino’s music maintained its popularity in certain circles, particularly among fans of early rock and roll and rhythm and blues. However, his commercial success began to wane as the music scene shifted. He still released albums during this period, though fewer songs charted on the pop charts.

Fat Domino’s music continued to be celebrated throughout the 1970s and 1980s, with a resurgence of interest in early rock and roll. He was inducted into the Rock and Roll Hall of Fame in 1986, and his work was widely recognized for its groundbreaking influence on rock and roll.

Domino's later albums, such as Fat Domino Rocks (1981) and The Fat Man: A Retrospective (1991), feature both classic hits and newer material, although he would eventually retire from active touring. His musical legacy is cemented by his pioneering role in shaping the sound of rock and roll, blending R&B rhythms with a rock-driven edge.